The Nikon D4S DSLR Camera features a full-frame, FX-format 16.2MP CMOS sensor and EXPEED 4 image processor to produce high-resolution still imagery and full HD 1080p movies with notable image detail, quality, and sensitivity. The combination of these two technologies affords exceptional image quality, marked by smooth tonal gradations and vivid, yet accurate, color reproduction as well as an expansive dynamic range. Championing working in a wide variety of lighting conditions, the D4S also features a broad native sensitivity range, from ISO 100-25600, that is further expandable to an equivalent ISO 409600 to benefit working in difficult lighting conditions. Furthermore, the processing power of the EXPEED 4 also affords a full-resolution continuous shooting rate of 11 fps for up to 200 frames with maintained auto-exposure and autofocus.

Aiding the imaging prowess of this camera is an equally refined 51-point autofocus system, which can be configured to utilize five AF points as a single focusing point in the Group Area AF setting for heightened initial subject recognition. The 3D Color Matrix Metering III system, along with the 91,000-pixel RGB sensor, also benefits the focusing abilities of the D4S as well as provides accurate exposure metering to suit a vast array of subjects and lighting conditions.

Complementing a fast, time-sensitive workflow, this camera also employs numerous strategies designed to benefit fast offloading and transferring of files. Support is available for a 1000 Base-T (Gigabit) wired LAN connection and file recording is possible in a 12-bit RAW SIZE S file size to help expedite post-production. When recording movies or time lapse imagery, optional external recorders can be used to record uncompressed movie files, with simultaneous recording to memory cards and live view monitoring possible.